831222-76-5Relevant academic research and scientific papers
Novel combretastatin analogues endowed with antitumor activity
Simoni, Daniele,Romagnoli, Romeo,Baruchello, Riccardo,Rondanin, Riccardo,Rizzi, Michele,Pavani, Maria Giovanna,Alloatti, Domenico,Giannini, Giuseppe,Marcellini, Marcella,Riccioni, Teresa,Castorina, Massimo,Guglielmi, Mario B.,Bucci, Federica,Carminati, Paolo,Pisano, Claudio
, p. 3143 - 3152 (2007/10/03)
We studied the anticancer activity of a series of new combretastatin derivatives with B-ring modifications. The structure-activity relationship (SAR) information confirmed the importance of cis-stereochemistry and of a phenolic moiety in B-ring. We select
COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION
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Page 35-36, (2010/02/10)
The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula (I) in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.
