831222-82-3Relevant academic research and scientific papers
COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION
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Page 38; 39-40, (2010/02/10)
The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula (I) in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.
