83124-79-2Relevant academic research and scientific papers
Enol ethers and acetals: Acylation with dichloroacetyl, acetyl and benzoyl chloride in ionic liquid medium
Guarda, Emerson A.,Marzari, Mara R.B.,Frizzo, Clarissa P.,Guarda, Patrícia M.,Zanatta, Nilo,Bonacorso, Helio G.,Martins, Marcos A.P.
supporting information; experimental part, p. 170 - 172 (2012/01/17)
Synthesis of 4-alkoxy-1,1-dichloro-3-alken-2-ones [CHCl2C(O) C(R2)C(R1)-OR, where R, R1, R2 = Et, H, H; Me, Me, H; Et, H, Me; Me, -(CH2)2-; Me, -(CH 2)3-; Et, Et, H; Et, Bu, H; Et, i-Pr, H; Et, i-Bu, H; Me, Ph, H; Me, thien-2-yl, H] from acylation of enol ethers and acetals with dichloroacetyl chloride, in ionic liquid ([BMIM][BF4] or [BMIM][PF6]) is reported. The synthesis of alkenones [R 3-C(O)C(R2)C(R1)-OR], where R/R 1/R2/R3 = Et/H/H/Ph, t-Bu/H/H/Ph, Me/-(CH 2)4/Ph, Me/-(CH2)4/Me] from the reaction of enol ethers with benzoyl chloride or acetyl chloride, in ionic liquid [BMIM][BF4], is also reported. Last products are described for the first time.
Enol Ethers, VIII. Acylation of Enol Ethers with Reactive Carbonyl Chlorides
Effenberger, Franz,Maier, Roland,Schoenwaelder, Karl-Heinz,Ziegler, Thomas
, p. 2766 - 2782 (2007/10/02)
Enol ethers 2 are acylated under mild conditions with activated acyl chlorides, e. g. chloroacetyl chlorides 1a, b, cyanoacetyl chloride (6c), and malonic acid chlorides 6a, b in good yields.The products formed and the yield depend on the acylation potential of the acyl chlorides.The potential β-keto aldehydes 4, 5, and 1,3,5-tricarbonyl compounds 8 obtained are valuable intermediates for heterocyclic synthesis.
