83128-61-4

Upstream product

• 837-32-1 1-cyclohexyl-5-ethyl-pyrimidine-2,4,6-trione 
• 698-90-8 N'-cyclohexylurea 
• 133-13-1 ethyl diethyl malonate 

Downstream Products

• 83129-39-9 (+/-)-1-Cyclohexyl-5-ethyl-5-dimethylamino-barbitursaeure 
• 221679-69-2 5-amino-1-cyclohexyl-5-ethylbarbituric acid 
• 221679-72-7 5-Azido-1-cyclohexyl-5-ethylbarbituric acid 
• 101693-71-4 (RS)-1-cyclohexyl-5-ethyl-5-(1-piperidinyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 
• 83128-75-0 (+)-1-Cyclohexyl-5-ethyl-5-piperidino-barbitursaeure 
• 83128-75-0 (-)-1-Cyclohexyl-5-ethyl-5-piperidino-barbitursaeure 
• 345932-03-8 (+/-)-1-Cyclohexyl-5-ethyl-5-pyrrolidino-barbitursaeure 
• 83128-82-9 (+)-1-Cyclohexyl-5-ethyl-5-pyrrolidino-barbitursaeure 
• 83128-82-9 (-)-1-Cyclohexyl-5-ethyl-5-pyrrolidino-barbitursaeure 

Relevant academic research and scientific papers

A new one-pot synthesis of 5,5-disubstituted hydantoins from diethyl acetamidomalonates and ureas

A new one-pot synthesis of 5,5-disubstituted hydantoins 3 is reported. Diethyl 2-acetamido-2-alkylmalonates were found to react with substituted ureas in the presence of sodium ethoxide to produce the 5-alkyl-5- carbamoylhydantoins 3 a-e. The reaction involves a ring contraction of intermediate 5-aminobarbituric acids to the final hydantoin derivatives. The 5-aminobarbituric acids 2 d-f were prepared from azido derivatives 6 d-f. On treatment with sodium ethoxide, 2 d-f underwent the rearrangement to afford the hydantoins 3 d-f.

Derivatives of Barbituric Acid, XXX: Synthesis of Racemic and Optically Active Barbituric Acids Carrying Basic Substituents

Monoalkylated malonates were condensed with N-monosubstituted ureas to yield the 5-monosubstituted barbituric acids 1, which were reacted to the 5-bromobarbituric acids 2.From 2 the barbituric acids 3-5 having basic substituents were obtained by nucleophi