832-83-7

Usage

General Description

1-ALLYL-3-HYDRAZONO-1,3-DIHYDRO-INDOL-2-ONE is a chemical compound with the molecular formula C11H12N2O. It is a derivative of the indole compound and contains an allyl group and a hydrazono group. 1-ALLYL-3-HYDRAZONO-1,3-DIHYDRO-INDOL-2-ONE has been studied for its potential biological activities, including its antimicrobial and antifungal properties. It has also been investigated for its potential use as a building block in organic synthesis. Overall, 1-ALLYL-3-HYDRAZONO-1,3-DIHYDRO-INDOL-2-ONE represents an interesting and potentially useful chemical compound with various potential applications in the fields of medicine and chemistry.

InChI:InChI=1/C11H11N3O/c1-2-7-14-9-6-4-3-5-8(9)10(13-12)11(14)15/h2-6H,1,7,12H2/b13-10+

Upstream product

• 830-74-0 1-allyl-1H-indole-2,3-dione 

Relevant academic research and scientific papers

Squaramide-catalyzed asymmetric Mannich reactions between 3-fluorooxindoles and pyrazolinone ketimines

An enantioselective Mannich reaction between 3-fluorooxindoles and pyrazolinone ketimines has been developed for the construction of amino-pyrazolone-oxindoles containing stereogenic C-F units. Based on this new protocol that allows for the generation of two adjacent tetrasubstituted stereocenters, a variety of structurally diverse fluorinated amino-pyrazolone-oxindoles were obtained in good to excellent yields with excellent diastereoselectivities and enantioselectivities (up to 98% yield, >20:1 dr and >99% ee). What's more, good yield and high stereoselectivities were obtained in the gram-scale reaction.

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.