832080-79-2Relevant academic research and scientific papers
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy
Sagar, Satish,Singh, Sarbjit,Mallareddy, Jayapal Reddy,Sonawane, Yogesh A.,Napoleon, John V.,Rana, Sandeep,Contreras, Jacob I.,Rajesh, Christabelle,Ezell, Edward L.,Kizhake, Smitha,Garrison, Jered C.,Radhakrishnan, Prakash,Natarajan, Amarnath
, (2021/06/22)
Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the activation loop serine residues (S177, S181) in IKKβ
QUINOXALINE COMPOUNDS AND USES THEREOF
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Page/Page column 24-25; 37, (2012/06/15)
Disclosed herein are compounds of formula (I) and methods of inhibiting ΙΚΚβ and the NF-κB signaling and mTOR pathways.
2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study
Chen, Qianyi,Bryant, Vashti C.,Lopez, Hernando,Kelly, David L.,Luo, Xu,Natarajan, Amarnath
, p. 1929 - 1932 (2011/04/24)
The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity
