83209-65-8 Usage
Uses
Used in Pharmaceutical Industry:
HC Toxin is used as an HDAC inhibitor for its potential therapeutic effects in treating colorectal cancer and other diseases. Its ability to up-regulate the expression of 15-lipoxygenase-1 and induce fetal hemoglobin makes it a promising candidate for further research and development.
Used in Agricultural Industry:
HC Toxin is used as a cyclic tetrapeptide fungal toxin that selectively targets plants with susceptible host genotypes. This property can be utilized for the development of targeted pest control strategies and crop protection methods.
Biochem/physiol Actions
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.
Check Digit Verification of cas no
The CAS Registry Mumber 83209-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,2,0 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83209-65:
(7*8)+(6*3)+(5*2)+(4*0)+(3*9)+(2*6)+(1*5)=128
128 % 10 = 8
So 83209-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14+,15+,17?/m0/s1
83209-65-8Relevant academic research and scientific papers
STEREOSELECTIVE SYNTHESIS OF HC TOXIN AND ITS (9R) EPOXIDE EPIMER
Jacquier, Robert,Lazaro, Rene,Raniriseheno, Hanta,Viallefont, Ph.
, p. 4735 - 4736 (2007/10/02)
HC Toxin and its (9R) epoxide epimer have been synthesized via the Sharpless epoxidation of the allylic alcohol precursor 2.The epoxyketone configuration has been assigned by circular dichroism spectroscopy.
Total synthesis of the cyclic tetrapeptide, HC-toxin
Kawai,Rich
, p. 5309 - 5312 (2007/10/02)
The amino acid sequence of the host-specific phytotoxin, HC-toxin, cyclo(L-Ala-D-Ala-L-Aoe-D-Pro) has been confirmed by total synthesis.
