832150-76-2Relevant academic research and scientific papers
Novel method for preparing thiophene formaldehyde compounds
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Paragraph 0032; 0033; 0042; 0043, (2019/08/20)
The present invention provides a novel method for preparing thiophene formaldehyde compounds by using cyclopropylethanol and K2S under metal-free catalytic conditions. The thiophene formaldehyde compounds are directly synthesized by using cyclopropylethan
Design and synthesis of arylthiophene-2-carbaldehydes via suzuki-miyaura reactions and their biological evaluation
Ali, Shaukat,Rasool, Nasir,Ullah, Aman,Nasim, Faiz-Ul-Hassan,Yaqoob, Asma,Zubair, Muhammad,Rashid, Umer,Riaz, Muhammad
, p. 14711 - 14725 (2014/01/17)
A series of various novel 4-arylthiophene-2-carbaldehyde compounds were synthesized in moderate to excellent yields via Suzuki-Miyaura cross-coupling with different arylboronic pinacol esters/acids. The synthesized products were screened for their antibacterial, haemolytic, antiurease, and nitric oxide (NO) scavenging capabilities and interestingly, almost all products turned out to have good activities. 3-(5-Formylthiophene- 3-yl)-5-(trifloromethyl)benzonitrile (2d) revealed excellent antibacterial activity, showing an IC50 value of 29.7 μg/mL against Pseudomonas aeruginosa, compared to the standard drug streptomycin with an IC50 value 35.2 μg/mL and was also found to be the best NO scavenger, with an IC50 value of 45.6 μg/mL. Moreover, 4-(3-chloro-4-fluorophenyl) thiophene-2-carbaldehyde (2i) exhibited a superior haemolytic action and an outstanding urease inhibition, showing an IC50 value of 27.1 μg/mL.
