83230-64-2Relevant academic research and scientific papers
propanolamines. 1. Novel β-Blockers with Ultrashort Duration of Action
Kam, Sheung-Tsam,Matier, William L.,Mai, Khuong X.,Barcelon-Yang, Cynthia,Borgman, Robert J.,et al.
, p. 1007 - 1016 (2007/10/02)
Novel propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.
METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS
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, (2008/06/13)
A method for the treatment or prophylaxis of cardiac disorders in a mammal, comprising administering to such mammal a short-acting β-blocking compound of the formula: STR1 wherein X is an ester-containing group; R may be lower alkyl, aralkyl or an ester-containing group; R 1 may be lower alkyl; and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Novel compounds possessing short acting β-adrenergic blocking activity are also disclosed.
