83234-94-0Relevant articles and documents
ENANTIOMERIC SYNTHESIS OF 2-ALLYL-4-HYDROXYPYRROLIDINE FRAMEWORK VIA IODINE-MEDIATED REACTION
Takano, Seiichi,Kasahara, Chiyoshi,Ogasawara, Kunio
, p. 1443 - 1447 (2007/10/02)
The amide (14), prepared from the symmetric amine 12 and a chiral acid, (S)-(-)-proline, furnished a mixture of the epimeric (2S,4R/S)-(-)-2-allyl-4-hydroxypyrrolidine derivatives in good yield upon reaction with iodine in an aqueous solvent.Chiralities of the both products are established by correlating them to (2S,4R)-(-)-4-hydroxyproline (27).