83254-82-4

Upstream product

• 536-90-3 m-Anisidine 
• 591-50-4 iodobenzene 
• 7699-19-6 6-methoxyoxindole 
• 64053-59-4 N-chloroacetyl-N-phenyl-m-anisidine 
• 101-16-6 3-methoxy-N-phenylaniline 
• 64053-58-3 6-Hydroxy-1-phenyl-1,3-dihydro-indol-2-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 63949-32-6 2-chloro-6-methoxy-1-phenyl-1H-indole-3-carbaldehyde 

Relevant academic research and scientific papers

CYCLIC INDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

The present invention relates to cyclic indole-3-carboxamides of the Formula (I), wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the Formula (I), their use and pharmaceutical compositions comprising them.

MONO(m-SUBSTITUTED) CHLOROACETYLDIARYLAMINES IN THE STOLLE REACTION

The effect of substituted (OCH3, Cl) on the ratio of the isomeric N-aryloxindoles formed in the Stolle reaction from mono(m-substituted) chloroacetyldiarylamines was studied.It was shown by means of gas-liquid chromatography (GLC) and PMR spectroscopy that in the case of the methoxy group electrophilic substitution occurs only in the ring activated by the substituent.The presence of a halogen atom leads only to 1-(m-chlorophenyl)oxindole.The results show that high selectivity of the attack by the carbonium ion on the phenyl rings with electron-donor and electron-acceptor substituents is also retained in the case of intramolecular electrophilic substitution under conditions of kinetic control.