83257-95-8

Basic information

• Product Name: Ethanol, 2,2'-[(4-nitro-1,2-phenylene)bis(oxy)]bis-
• CAS NO: 83257-95-8
• Molecular Formula: C10H13NO6
• Molecular Weight: 243.216
• Mol File: 83257-95-8.mol

Chemical Properties

• CAS DataBase Reference: Ethanol, 2,2'-[(4-nitro-1,2-phenylene)bis(oxy)]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2,2'-[(4-nitro-1,2-phenylene)bis(oxy)]bis-(83257-95-8)
• EPA Substance Registry System: Ethanol, 2,2'-[(4-nitro-1,2-phenylene)bis(oxy)]bis-(83257-95-8)

Safety Data

• Hazardous Substances Data: 83257-95-8(Hazardous Substances Data)

Upstream product

• 10234-40-9 2,2'-(1,2-phenylenedioxy)diethanol 
• 180532-07-4 2,2'-[(4-nitro-1,2-phenylene)bis(oxy)]bis[acetic acid] dimethyl ester 
• 3316-09-4 1,2-dihydroxy-4-nitrobenzene 

Downstream Products

• 97916-49-9 4-nitro-1,2-bis(2-chloroethoxy)benzene 
• 68941-06-0 4-aminobenzo-18-crown-6 
• 53408-96-1 4'-nitrobenzo-18-crown-6 

Relevant articles and documents

NOVEL INHIBITORS OF BETA-LACTAMASE

This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.

NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE

This invention provides novel β-lactamase inhibitors of the aryl-and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or a pro-drug or pharmaceutically acceptable salt thereof, wherein: W represents: Formula (II).

SYNTHESIS OF NITRO AND AMINO DERIVATIVES OF THE MACROCYCLIC POLYETHER 2,3-BENZO-1,4,7,10,13,16-HEXAOXACYCLOOCTADEC-2-ENE

Convenient methods were developed for the synthesis of 1,2-di(2-hydroxyethoxy)benzene, 1,2-di(2-hydroxyethoxy)-4-nitrobenzene, and 1,2-di(2-hydroxyethoxy)-4,6-dinitrobenzene - the intermediate products in the synthesis of nitro and amino derivatives of 2,3-benzo-1,4,7,10,13,16-hexaoxacyclodec-2-ene (benzo-18-crown-6).The effect of the nature of the solvent on the yield of mono- and dinitro derivatives of 1,2-di(2-hydroxyethoxy)benzene in the nitration of the latter was investigated.It was shown that benzo-18-crown-6 and dicyclohexyl-18-crown-6 have a catalytic effect on the yield of the products from O-alkylation of 1,2-dihydroxybenzene and its derivatives.