83268-65-9

Basic information

• Product Name: 6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
• CAS NO: 83268-65-9
• Molecular Weight: 410.554
• Mol File: 83268-65-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one(83268-65-9)
• EPA Substance Registry System: 6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one(83268-65-9)

Safety Data

• Hazardous Substances Data: 83268-65-9(Hazardous Substances Data)

Upstream product

• 79691-11-5 6(R)-<2-<1,2,6,7,8,8a(R)-Hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-1(S)-naphtyl>ethyl>-3,4,5,6-tetrahydro-4(R)-<(tert-butyldimethylsilyl)oxy>-2H-pyran-2-one 
• 75330-75-5 lovastatin 
• 83268-63-7 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran 
• 79691-13-7 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran 
• 79691-14-8 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<1,2,6,7,8,8a(S)-hexahydro-8(S)-hydroxy-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-<(tetrahydropyran-2-yl)oxy>-3,4,5,6-tetrahydro-2H-pyran 
• 83268-64-8 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<8(S)-(benzyloxy)-1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran 
• 79691-12-6 4(R)-(tert-butyldimethylsiloxy)-6(R)-<2-<1,2,6,7,8,8a(S)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-1(S)-naphthyl>ethyl>-2-hydroxy-3,4,5,6-tetrahydro-2H-pyran 

Relevant articles and documents

Structural Modification of Mevinolin

Synthetic strategies are described for modifying the side-chain ester and lactone moieties of mevinolin (1), a potent, competitive HMG-CoA reductase inhibitor isolated from cultures of Aspergillus terreus.A general route for preparing side-chain ether analogues of 1 is disclosed.Central to the success of this multistep route is the use of a method for reversibly masking the lactone moiety as a hemiacetal ether.The merit of this strategy is demonstrated again in the route developed for elaborating mevalonate analogue 11 from 1.Finally, a new, versatile, and efficientmethod is presented for homologating five- and six-membered lactones and is used to prepare carboxylate 27, a homologue of 1.