832735-68-9Relevant academic research and scientific papers
The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil
Dutta, Uttam,Deb, Arghya,Lupton, David W.,Maiti, Debabrata
supporting information, p. 17744 - 17747 (2015/12/18)
A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed.
Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease
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Paragraph 0541; 0542; 0559; 0560, (2014/12/09)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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Page/Page column 107; 108; 112, (2014/12/12)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
