832739-11-4Relevant academic research and scientific papers
β-Glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2′-deoxyguanosine
Wei, Guangping,Loktionova, Natalia A.,Pegg, Anthony E.,Moschel, Robert C.
, p. 256 - 261 (2005)
Glucuronic acid linked prodrugs of O6-benzylguanine and O 6-benzyl-2′-deoxyguanosine were synthesized. The prodrugs were found to be quite stable at physiological pH and were more than 200-fold less active as inactivators of O6
BETA-GLUGURONIDASE CLEAVABLE PRODRUGS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS
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Page/Page column 18, (2010/10/20)
Disclosed are prodrugs of inactivators of 06-alkylguanine-DNA alkyltransferase (AGT). The prodrugs are cleavable by the (3-glucuronidase enzyme, which is either administered to the patient or produced by necrotic tumor cells. The prodrugs are r
