83282-40-0Relevant academic research and scientific papers
Antiallergic agents. III. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides
Honma,Hanamoto,Hashiyama,et al.
, p. 125 - 128 (2007/10/02)
A series of N-tetrazolylpyridinecarboxamides was prepared and evaluated for antiallergic activity by the passive cutaneous anaphylaxis assay. From the structure-activity relationships of this class of compounds, it was revealed that the N-tetrazolylcarbamoyl group as an acidic functionality is required to be at the 2-position of the pyridine nucleus and that the phenyl group as a substituent is not necessarily required for activity. 6-Methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide showed good oral activity and low toxicity.
2-Pyridinecarboxamide derivatives compositions containing same and method of using same
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, (2008/06/13)
A 2-pyridinecarboxamide derivative of the formula: STR1 wherein R1 is hydrogen, lower alkyl, lower alkoxy, halogen, lower alkyl-thio or nitro and is in the 3rd-, 4th- or 5th-position of the pyridyl group, and R2 is hydrogen, lower alkyl, lower alkoxy, phenoxy, phenyl-lower alkyl, phenyl-lower alkenyl, or halogen. Said 2-pyridinecarboxamide derivative (I) or a pharmaceutically acceptable salt thereof is useful as an anti-allergic agent.
