Welcome to LookChem.com Sign In|Join Free
  • or
Iproplatin, also known as (cis, trans, cis)-diammine-(cyclohexane-1,1-diyl-dimethylene)-dichloroplatinum(II), is a platinum-based chemotherapy drug. It is a platinum coordination complex that works by disrupting DNA replication and cell division, ultimately leading to the death of rapidly dividing cancer cells. Its mechanism of action is similar to other platinum-based drugs, such as cisplatin and carboplatin, but it may have different side effects and efficacy profiles.
Used in Oncology:
Iproplatin is used as a chemotherapy agent for the treatment of various cancers, including ovarian, bladder, and lung cancer. It is particularly effective against solid malignancies due to its ability to target rapidly dividing cancer cells.
Used in Combination Therapy:
Iproplatin is often used in combination with other chemotherapy drugs to enhance the overall treatment efficacy and overcome drug resistance in cancer cells.
Used as Second-Line Treatment:
In cases where patients have not responded to other therapies, iproplatin may be used as a second-line treatment to provide an alternative approach to managing the disease.
Despite its potential toxicity, which can cause common side effects such as nausea, vomiting, and bone marrow suppression, iproplatin is considered an important drug in the oncology field for its role in cancer treatment. It is typically administered intravenously to ensure proper dosage and distribution within the body.

83291-20-7

Post Buying Request

83291-20-7 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

83291-20-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 83291-20-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,2,9 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83291-20:
(7*8)+(6*3)+(5*2)+(4*9)+(3*1)+(2*2)+(1*0)=127
127 % 10 = 7
So 83291-20-7 is a valid CAS Registry Number.
InChI:InChI=1/2C3H9N.2ClH.2H2O.Pt/c2*1-3(2)4;;;;;/h2*3H,4H2,1-2H3;2*1H;2*1H2;/q;;;;;;+4/p-4

83291-20-7Downstream Products

83291-20-7Relevant academic research and scientific papers

Molecular interaction fields vs. quantum-mechanical-based descriptors in the modelling of lipophilicity of platinum(iv) complexes

Ermondi, Giuseppe,Caron, Giulia,Ravera, Mauro,Gabano, Elisabetta,Bianco, Sabrina,Platts, James A.,Osella, Domenico

supporting information, p. 3482 - 3489 (2013/03/28)

We report QSAR calculations using VolSurf descriptors to model the lipophilicity of 53 Pt(iv) complexes with a diverse range of axial and equatorial ligands. Lipophilicity is measured using an efficient HPLC method. Previous models based on a subset of these data are shown to be inadequate, due to incompatibility of whole molecule descriptors between carboxylato and hydroxido ligands. Instead, the interaction surfaces of complexes with various probes are used as independent descriptors. Partial least squares modelling using three latent variables results in an accurate (R2 = 0.92) and robust model (Q2 = 0.87) of lipophilicity, that moreover highlights the importance of size and hydrophobicity terms and the modest relevance of hydrogen bonding.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 83291-20-7