83293-77-0

Usage

Chemical structure

Contains a naphthalene core with a 1,4-dione functional group and a hydroxyethylsulfanyl side chain.

Usage

Commonly used in the production of dyes, pigments, and fluorescent brighteners.

Function

Acts as a reactive dye intermediate and can be used to modify the color and properties of various materials.

Applications

Used in healthcare and pharmaceutical industries as a precursor for the synthesis of various drugs and pharmaceutical compounds.

Safety

Should be handled and used with caution, as it may pose health hazards if not properly managed.

Upstream product

• 60-24-2 2-hydroxyethanethiol 
• 130-15-4 [1,4]naphthoquinone 

Relevant academic research and scientific papers

Synthesis, antitumor activity and docking of 2,3-(substituted)-1,4-naphthoquinone derivatives containing nitrogen, oxygen and sulfur

Eleven 2,3-(substituted)-1,4-naphthoquinone derivatives were synthesized in yields ranging from 52-89percent. These derivatives were evaluated for their cytotoxic effects on human lungs (H460), triple-negative breast (MDA-MB-231) and ovarian (A2780) cancer cell lines. Compounds 5f and 8 showed IC50 values of 3.048 × 10-5 mol L-1 and 4.24 × 10-6 mol L-1 for H460; 5c and 8 showed IC50 values of 2.16 × 10-5 mol L-1 and 1.60 × 10-5 mol L-1 for MDA-MB-231, and 5g and 8 showed IC50 values of 2.68 × 10-6 mol L-1 and 3.89 × 10-6 mol L-1 for A2780. Additionally, we conducted a docking study with the four most active compounds and the therapeutic targets PI3K and topoisomerase II showing the pharmacophoric conformation of these compounds.