83325-02-4Relevant academic research and scientific papers
Aryl-Substituted Purines, I. - Synthesis of 7-Phenylguanine and of 2-Substituted 7-Arylhypoxanthines
Verkoyen, Carl,Golovinsky, Evgeny,Mueller, Gunther,Koelbel, Margit,Norpoth, Klaus
, p. 957 - 960 (2007/10/02)
The synthesis of 7-phenylguanine (2) by cyclisation reaction of ethyl 4-amino-1-phenyl-5-imidazolecarboxylate (1a) with cyanamide is described.This reaction is the first and hitherto only synthetic approach to a hypothetical base adduct the significance of which is discussed in relation to the carcinogenesis of benzene.Moreover, the 2-substituted 7-arylhypoxanthines 4a-e have been prepared by reaction of ethyl 1-aryl-4-amino-5-imidazolecarboxylates 1a-c with thioamides 3a-c.Formic acid proved to be the best catalyst.By this new procedure starting compounds for the d evelopment of a radioimmuno assay for the trace analysis of 2 can be prepared in good yields.
PHOSPHORUS PENTOXIDE IN ORGANIC SYNTHESIS-I. PHOSPHORUS PENTOXIDE-AMINE HYDROCHLORIDE MIXTURES AS REAGENTS IN A NEW SYNTHESIS OF HYPOXANTHINES
Nielsen, F. E.,Pedersen, E. B.
, p. 1435 - 1442 (2007/10/02)
A series of 23 new 1,7-dihydro-6H-purin-6-ones, 3a-3w have been prepared by heating ethyl 4-acylamino-1H-imidazole-5-carboxylates, 2a-2f and 2h, with primary amine hydrochlorides and phosphorus pentoxide in N,N-dimethylcyclohexylamine.Imidazoo
