83326-76-5

Basic information

• Product Name: Benzoic acid, 2-hydroxy-6-pentyl-
• CAS NO: 83326-76-5
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol File: 83326-76-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-6-pentyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-6-pentyl-(83326-76-5)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-6-pentyl-(83326-76-5)

Safety Data

• Hazardous Substances Data: 83326-76-5(Hazardous Substances Data)

Upstream product

• 86791-43-7 ethyl 2-hydroxy-6-pentylbenzoate 
• 164014-40-8 2,2-dimethyl-5-trifluoromethylsulfonyloxy-4H-(1,3)benzodioxin-4-one 
• 627-19-0 1-Pentyne 
• 1357171-06-2 2,2-dimethyl-5-pentyl-4H-benzo[d][1,3]dioxin-4-one 
• 164014-48-6 2,2-dimethyl-5-(pent-1-yn-1-yl)-4H-benzo[d][1,3]dioxin-4-one 
• 86791-42-6 ethyl 2-hydroxy-6-pentyl-4-(1-phenyl-5-tetrazolyl)-oxybenzoate 
• 58497-40-8 3,5-dibromo-2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester 
• 38862-65-6 2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester 
• 214750-30-8 3-butyl-7-methoxyphthalide 
• 591-31-1 3-methoxy-benzaldehyde 

Relevant articles and documents

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elu

Inhibition of prostaglandin biosynthesis by 4-O-methylcryptochlorophaeic acid; synthesis of monomeric arylcarboxylic acids for inhibitory activity testing and X-ray analysis of 4-O-methylcryptochlorophaeic acid

In order to clarify the structure-activity relationship of 4-O-methylcryptochlorophaeic acid (1), which is a lichen meta-depside and a potent inhibitor of prostaglandin (PG) biosynthesis found in our previous screening work, arylcarboxylic acids (5-8) corresponding to the monomeric moieties of 4-O-methylcryptochlorophaeic acid (1) were synthesized and tested for inhibitory effect against PG biosynthesis by an enzyme system prepared from rabbit renal medulla. They were a hundred times less active that 4-O-methylcryptochlorophaeic acid (1), indicating that the dimeric structure of the meta-depside is essential for inhibitory activity against PG biosynthesis. Kinetic studies on the mechanism of inhibition revealed that 4-O-methylcryptochlorophaeic acid (1) inhibits PG biosynthesis competitively with respect to the substrate, arachidonic acid. The three dimensional structure of 4-O-methylcryptochlorophaeic acid (1), which is expected to have a molecular structure able to fit into an active site that accommodates arachidonic acid, was determined by single crystal X-ray analysis with the direct approach. The obtained structure reveals that 4-O-methylcryptochlorophaeic acid (1) maintains a rigid conformation by forming a strong hydrogen bond between a hydroxy group and a methoxy group. Based on these findings, a new active site model of fatty acid cylooxygenase is proposed in order to explain the inhibition by the meta-depside and acidic non-steroidal antiinflammatory drugs.