833430-30-1Relevant articles and documents
Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening
Ma, Hao,Zhuang, Chunlin,Xu, Xiguo,Li, Jiao,Wang, Juan,Min, Xiao,Zhang, Wannian,Zhang, Huojun,Miao, Zhenyuan
, p. 174 - 183 (2017)
NEDD8 activating enzyme (NAE) plays a critical role in various cellular functions in cancers. In this study, a target-based virtual screening was applied to discover benzothiazoles to be potent non-covalent NAE inhibitors. Further two round optimizations