83344-16-5Relevant academic research and scientific papers
LACTAMISATION PAR LE BOP: ACETYL-3 METHYL-7 PHTALIMIDO-7 CEPHEME
Roze, J. C.,Pradere, J. P.,Duguay, G.,Guevel, A.,Quiniou, H.
, p. 2315 - 2318 (1982)
A 1,3-thiazine with a prelactamic chain is obtained via a (4+2) cycloaddition reaction.The regioselective hydrogenation at 2,3 and subsequent lactamisation using BOP is described.
Enchainements heteroatomiques et leurs produits de cyclisation. VI. Nouvelle synthese de cephemes: acetyl-3 methyl-7 phtalimido-7 oxo-8 thia-5 aza-1 bycyclooctenes-2 diastereomers
Roze, Jean-Claude,Pradere, Jean-Paul,Duguay, Guy,Guevel, Andre,Quiniuo, Herve,Poignant, Serge
, p. 1169 - 1175 (2007/10/02)
The total synthesis of two diastereomeric cephems is described with three original steps in excellent yields: construction of the 1,3-thiazine ring via a (4+2) cycloaddition reaction, regioselective hydrogenation of the carbon-nitrogen double bond, and la
