833457-45-7Relevant academic research and scientific papers
2-PHENYL-6-AZOLYLPYRIDINE-BASED LIGAND AND GROUP VIII TRANSITION METAL COMPLEX
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, (2013/03/26)
A 2-phenyl-6-azolylpyridine-based ligand is represented by the following formula (I): wherein, X represents nitrogen or C—R10; R1, R2, R3, R4, R5, R6, R7, R8 /su
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Cai, Jiaqiang,Fradera, Xavier,Van Zeeland, Mario,Dempster, Maureen,Cameron, Kenneth S.,Bennett, D. Jonathan,Robinson, John,Popplestone, Lucy,Baugh, Mark,Westwood, Paul,Bruin, John,Hamilton, William,Kinghorn, Emma,Long, Clive,Uitdehaag, Joost C.M.
scheme or table, p. 4507 - 4510 (2010/10/21)
Using computer aided modelling studies, a new extended P2/S2 interaction was identified. This extended region can accommodate a variety of functional groups, such as aryls and basic amines. It was discovered that the N3 nitrogen of the pyrimidine-2-carbonitrile is critical for its cathepsin cysteine protease inhibition. N1 nitrogen also contributes to the inhibitory activity, but to a very limited degree. An 'in situ double activation' mechanism was proposed to explain these results.
