833476-48-5

Upstream product

• 833476-66-7 (R)-3-[(E)-(4R,5R)-5-(4-Bromo-phenyl)-5-hydroxy-2,4-dimethyl-pent-2-enoyl]-4-isopropyl-oxazolidin-2-one 
• 833476-42-9 (4R,1'E,3'E)-(-1'-{[tert-butyl(dimethyl)silyl]oxy}-2'-methyl-1',3'-pentadienyl)-4-isopropyl-1,3-oxazolidin-2-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 833476-46-3 (R)-3-[(E)-(4R,5R)-5-(4-Bromo-phenyl)-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pent-2-enoyl]-4-isopropyl-oxazolidin-2-one 

Downstream Products

• 114127-18-3 (+)-(R)-trichostatin acid 
• 157479-37-3 trichostatin D 
• 833476-50-9 (2E,4E)-(6R,7R)-7-(4-Bromo-phenyl)-7-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethyl-hepta-2,4-dienoic acid 
• 833476-52-1 (2E,4E)-(6R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-7-(4-dimethylamino-phenyl)-4,6-dimethyl-hepta-2,4-dienoic acid 
• 833476-69-0 (2E,4E)-(6R,7R)-7-(4-Bromo-phenyl)-7-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethyl-hepta-2,4-dienoic acid ethyl ester 

Relevant academic research and scientific papers

The first total synthesis of trichostatin D

Trichostatin D and 6-epi-trichostatin D have been stereoselectively synthesized through a remote stereoinduction with a chiral vinylketene silyl N,O-acetal and glycosylation of hydroxyimide under Mitsunobu conditions.