833486-33-2Relevant academic research and scientific papers
The synthesis of N-heterocycles via copper/TEMPO catalysed aerobic oxidation of amino alcohols
Flanagan, James C. A.,Dornan, Laura M.,McLaughlin, Mark G.,McCreanor, Niall G.,Cook, Matthew J.,Muldoon, Mark J.
supporting information; experimental part, p. 1281 - 1283 (2012/06/04)
N-Heterocycles can be prepared using alcohol oxidation as a key synthetic step. Herein we report studies exploring the potential of Cu/TEMPO as an aerobic oxidation catalyst for the synthesis of substituted indoles and quinolines.
Synthesis of five-, six-, and seven-membered ring lactams by Cp*Rh complex-catalyzed oxidative N-heterocyclization of amino alcohols
Fujita, Ken-Ichi,Takahashi, Yoshinori,Owaki, Maki,Yamamoto, Kazunari,Yamaguchi, Ryohei
, p. 2785 - 2788 (2007/10/03)
A new effective catalytic system consisting of [Cp*RhCl 2]2/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the lactamization of amino alcohols has been developed. As an example, the reaction of 3-(2-aminophenyl)-1-propanol in the presence of [Cp*RhCl2]2 (5.0% Rh) and K 2CO3 (10%) in acetone gives 3,4-dihydro-2(1H)-quinolinone in an isolated yield of 80%. A variety of five-, six-, and seven-membered benzo-fused lactams are synthesized by this catalytic system.
