833487-73-3

Upstream product

• 834889-17-7 N-{(SR)-[(1RS,2SR)-2-{(1R)-2-[(tert-butyldiphenylsilanyl)oxy]-1-methylethyl}-1-methylcyclopropyl](phenyl)methyl}-P,P-diphenylphosphinamide 
• 833487-53-9 (1SR,2E,4R)-N-[5-(tert-butyldiphenylsilanyloxy)-2,4-dimethyl-1-phenylpent-2-enyl]-P,P-diphenylphosphinamide 
• 834889-17-7 C₄₂H₄₈NO₂PSi 
• 833487-62-0 {(S)-[(1R,2S)-2-((1R)-2-hydroxy-1-methylethyl)-1-methylcyclopropyl](phenyl)methyl}carbamic acid benzyl ester 
• 833487-71-1 {(S)-[(1R,2S)-1-methyl-2-((1R)-1-methyl-2-oxoethyl)cyclopropyl](phenyl)methyl}carbamic acid benzyl ester 
• 194610-24-7 (4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne 

Relevant academic research and scientific papers

Convergent approach to (E)-alkene and cyclopropane peptide isosteres

(Chemical Equation Presented) Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These

Imine additions of internal alkynes for the synthesis of trisubstituted (E)-alkene and cyclopropane peptide isosteres

Divergent multi-component reactions (DMCR) involving C-C bond formations can provide large increases in structural diversity and allow the rapid assembly of complex products from readily available starting materials. Cascade hydrozirconation-Zr/Zn transmetalation-imine addition of alkynes represents a versatile methodology for the synthesis of (E)-alkene and cyclopropane dipeptide isosteres. Appropriate substitutions at the sp2-carbon of (E)-alkene peptide isosteres allow a range of Pd-catalyzed cross-coupling reactions, which can be used for the fine-tuning of the conformational and electronic properties of the parent peptide bond mimic. C-C bond formation by microwave-accelerated Stille coupling of stannylalkenes represents a fast, convergent synthetic approach toward trisubstituted (E)-alkene dipeptide isosteres.