83369-15-7Relevant articles and documents
Fused Pyrimidines. I. The Chlorination of 2,4(1H,3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines
Miki, Hideci
, p. 1947 - 1951 (2007/10/02)
In the reaction of 2,4(1H,3H)-quinazolinedione with phosphoryl chloride in the presence of excess N-methylpyrrolidine, the hydroxy groups at the 2- and 4-position of the quinazoline nucleus were replaced by the N-methyl-4-chlorobutylamino group and chlorine to give 4-chloro-2-(N-methyl-4-chlorobutylamino)quinazoline in good yield.By using this reaction, several new 4-chloro-2-dialkylaminoquinazoline derivatives were obtained from N-alkylcyclic amines and 2,4(1H,3H)-quinazolinedione.Keywords --- N-alkylcyclic amine; pyrrolidine; piperidine; 2,4(1H,3H)-quinazolinedione; chlorination; amination; substitution reaction; ammonium salt; 4-chloro-2-dialkylaminoquinazoline