Welcome to LookChem.com Sign In|Join Free

CAS

  • or

83373-60-8

Post Buying Request

83373-60-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

83373-60-8 Usage

Description

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.

Chemical Properties

white to off-white solid

Uses

D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

Biochem/physiol Actions

D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.

references

1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.

Check Digit Verification of cas no

The CAS Registry Mumber 83373-60-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,3,7 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83373-60:
(7*8)+(6*3)+(5*3)+(4*7)+(3*3)+(2*6)+(1*0)=138
138 % 10 = 8
So 83373-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);

83373-60-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma

  • (T8543)  O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt  ≥95%, solid

  • 83373-60-8

  • T8543-5MG

  • 2,146.95CNY

  • Detail
  • Sigma

  • (T8543)  O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt  ≥95%, solid

  • 83373-60-8

  • T8543-25MG

  • 8,617.05CNY

  • Detail

83373-60-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name D609,O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate

1.2 Other means of identification

Product number -
Other names TRICYCLODECAN-9-YL XANTHOGENATE K

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83373-60-8 SDS

83373-60-8Upstream product

83373-60-8Downstream Products

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 83373-60-8