83375-61-5Relevant academic research and scientific papers
A Convenient Synthesis of 4-Unsubstituted β-Lactams
Overman, Larry E.,Osawa, Tatsushi
, p. 1698 - 1701 (2007/10/02)
The reaction of lithium ester enolates with N-(cyanomethyl)amines affords 4-unsubstituted β-lactams in good yields, see eq 1.The N-1 substituent can be varied widely, as can the C-3 substituents, which can be H, alkyl, SPh, NH2, or NHCOR.The preparation o
Synthesis of β-lactam antibiotics by the sulfeno-cycloamination
Ihara,Haga,Yonekura,et al.
, p. 7345 - 7352 (2007/10/02)
A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.
NOVEL STEREOSELECTIVE SYNTHESIS OF β-LACTAMS VIA EPISULFONIUM ION INTERMEDIATE
Ihara, Masataka,Fukumoto, Keiichiro
, p. 1435 - 1438 (2007/10/02)
A number of monocyclic β-lactams were synthesized by addition of benzenesulfonyl chloride to α,β-unsaturated olefins followed by base treatment in the presence of a phase transfer catelyst.The cyclization proceeds in a stereoselective manner most probably
