83387-25-1 Usage
Description
Methylnaltrexone, also known as Relistor, is the methylated, quaternary form of naltrexone. Its permanently charged nitrogen prevents the drug from crossing the blood-brain barrier, allowing it to act solely as an antagonist at peripheral opioid receptors.
Uses
Used in Pharmaceutical Industry:
Methylnaltrexone is used as a treatment for opioid-induced constipation in patients receiving palliative care. It is administered as a subcutaneous injection once every other day, providing relief from constipation without affecting the central nervous system due to its inability to cross the blood-brain barrier.
Check Digit Verification of cas no
The CAS Registry Mumber 83387-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,3,8 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83387-25:
(7*8)+(6*3)+(5*3)+(4*8)+(3*7)+(2*2)+(1*5)=151
151 % 10 = 1
So 83387-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22?/m1/s1
83387-25-1Relevant articles and documents
Quaternary derivatives of noroxymorphone which relieve intestinal immobility
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, (2008/06/13)
Compounds of the formula STR1 wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, and X is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion; the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
