83389-06-4

Upstream product

• 75-30-9 2-iodo-propane 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 
• 75-31-0 isopropylamine 

Downstream Products

• 87296-82-0 4-Chloro-2-isopropylamino-benzoic acid N',N'-dimethyl-hydrazide 
• 81822-07-3 7-Chloro-2-(2-fluoro-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 95216-81-2 7-Chloro-2-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-quinazolin-4-one 
• 81822-24-4 7-Chloro-2-(4-chloro-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 81822-25-5 7-Chloro-2-(4-fluoro-phenyl)-1-isopropyl-1H-quinazolin-4-one 
• 95216-80-1 7-chloro-2,3-dihydro-1-isopropyl-2-phenyl-4(1H)-quinazolinone 
• 81822-21-1 7-chloro-1-isopropyl-2-phenyl-4(1H)-quinazolinone 
• 81822-50-6 4-Chloro-2-isopropylamino-benzamide 

Relevant academic research and scientific papers

Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives

A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.

COMPOSES SULFURES HETEROCYCLIQUES. XCVI. REACTION DE L'HYDRAZINE SUR LES DIHYDRO-1,2 BENZOTHIAZINE-3,1 THIONES-4

1-Alkyl-1,2-dihydro-3,1-benzothiazine-4-thiones 1, when reacting with hydrazine, give with a good yield a 1-alkyl-3-amino-2,3-dihydro-1H-quinazoline-4-thione-2, often together with a derivative of 1,3,4-thiadiazole-3. With 1-aryl-1,2-dihydro-3,1-benzothiazine-4-thiones, the main product of the reaction with hydrazine appears to be a 1-aryl-4-hydrazono-1,4-dihydro-2H-3,1-benzothiazine 4, sometimes with some amount of 3.On the contrary, when reacting with hydrazine, 1-alkyl (or 1-aryl)-1,2-dihydro-3,1-benzothiazin-4-ones lead to a 2-alkylamino (or arylamino)-benzohydrazide 5. By thermolysis 4 isomerizes into 2 which is accompanied by derivatives (3 and 7) of 1,3,4-thiadiazole.The structures of compounds 2, 4 and 7 have been studied by NMR and UV spectrometry.