83395-25-9

Usage

InChI:InChI=1/C12H13N5O4/c1-20-11(18)15-10-13-8(16-5-3-2-4-6-16)7-9-14-12(19)21-17(9)10/h2-3,7H,4-6H2,1H3,(H,13,15,18)

Upstream product

• 83395-24-8 5-amino-7-<3,6-dihydro-1(2H)-pyridyl>-2H-<1,2,4>-oxadiazolo<2,3-c>pyrimidin-2-one 
• 69380-73-0 benzoimidazole-1-carboxylic acid methyl ester 
• 74025-90-4 2-amino-6-(methoxycarbonylamino)-4-(1,2,3,4-tetrahydro-1-pyridyl)pyrimidine 1-oxide 
• 68020-77-9 methyl 5-<3,6-dihydro-1(2H)-pyridyl>-2-oxo-2H-<1,2,4>-oxadiazolo<2,3-a>pyrimidine-7-carbamate 
• 61985-23-7 methyl 1-imidazolecarboxylate 

Relevant academic research and scientific papers

61. Synthesis of 2-Oxo-2H-oxadiazolo-pyrimidine-5-carbamates

Thermal cyclization of the pyrimidine-N-oxide dicarbamate 2 gives a 95:5 mixture of the 2-oxo-2H-oxadiazolo- and pyrimidinecarbamates 3 and 4.An efficient procedure for the conversion of 3 to 4, and vice versa, is described.

7[3,6-Dihydro-1(2H)-pyridyl]-2-oxo-2H-[1,2,4]oxadiazolo[2,3-c]pyrimidine-5-carbamate compounds

Oxadiazolo[2,3-c]pyrimidine derivatives of the formula STR1 wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable, long-lasting vasodilating and/or blood pressure-lowering properties and are useful for the treatment of vascular-conditioned hypertensions or as vasodilators in peripheral blood supply disorders. The compounds are prepared, inter alia, by carbamoylating the corresponding derivative containing a free amino group and optional salt formation.