83410-38-2 Usage
General Description
5-Bromo-2-methylpyrimidine-4-carboxylic acid ethyl ester, also known as ethyl 5-bromo-2-methylpyrimidine-4-carboxylate, is a chemical compound with the molecular formula C8H9BrN2O2. It is a derivative of pyrimidine and is commonly used as a building block in the synthesis of pharmaceutical compounds and agrochemicals. 5-Bromo-2-methylpyrimidine-4-carboxylic acid ethyl ester is characterized by its high reactivity, which allows for the modification and functionalization of its pyrimidine ring. It is often used in medicinal and chemical research and development, and its unique structure and properties make it valuable in the production of various organic and medicinal compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 83410-38-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,4,1 and 0 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 83410-38:
(7*8)+(6*3)+(5*4)+(4*1)+(3*0)+(2*3)+(1*8)=112
112 % 10 = 2
So 83410-38-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9BrN2O2/c1-3-13-8(12)7-6(9)4-10-5(2)11-7/h4H,3H2,1-2H3
83410-38-2Relevant articles and documents
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors
Lu, Hejun,Tu, Wangyang,Fei, Hongbo,Xu, Guoji,Hu, Qiyue,Zhang, Lei,Lin, Bing,Yuan, Jijun,Yin, Junzhao,Gong, Aishen,Wan, Mimi,Wang, Dan,Zhu, Xiaoyan,Feng, Jun,Wang, Qian,Sun, Piaoyang
, p. 2555 - 2559 (2014/05/20)
The MAPK pathway is identified as one of the most important pathways involved in cell proliferation and differentiation. A key kinase in the pathway, the Mitogen-activated protein kinase kinase (MEK) is recognized as a promising target for antitumor drugs. Structure-based design and optimization of known MEK inhibitors resulted in identification of compound 10a as a potent non-ATP competitive MEK inhibitor in both in vitro and in vivo tests.
