83416-73-3

Upstream product

• 254990-68-6 2-benzylpropane-1,3-diazide 
• 90918-19-7 benzyl malonamide 
• 40548-57-0 methanesulfonic acid 2-benzyl-3-methanesulfonyloxy-propyl ester 
• 2612-30-8 2-benzyl-1,3-propanediol 

Downstream Products

• 463299-16-3 CoBr₂(HONC(CH₃)C(CH₃)NCH₂CH(CH₂NC(CH₃)C(CH₃)NO)CH₂C₆H₅)^(1-) 
• 908094-98-4 N-[3-amino-2-benzylpropyl]acetamide 
• 1133712-99-8 (R)-(-)-allyl (3-amino-2-benzylpropyl)carbamate 
• 463299-10-7 CoBr₂(HONC(CH₃)C(CH₃)NCH₂CH(CH₂NC(CH₃)C(CH₃)NO)CH₂C₆H₅) 
• 463299-11-8 CoBr₂(HONC(C₂H₅)C(CH₃)NCH₂CH(CH₂NC(CH₃)C(C₂H₅)NO)CH₂C₆H₅) 
• 256653-40-4 N-acetyl-N-[3-diacetylamino-2-(4-nitro-benzyl)-propyl]-acetamide 
• 256653-39-1 N-acetyl-N-(2-benzyl-3-diacetylamino-propyl)-acetamide 

Relevant academic research and scientific papers

Enzymatic desymmetrization of prochiral 2-substituted-1,3-diamines: Preparation of valuable nitrogenated compounds

A wide range of prochiral 1, 3-diamines were first efficiently synthesized and subsequently desymmetrized by using lipase from Pseudomonas cepacia as catalyst and diallyl carbonate as alkoxycarbonylating agent. In all cases, the amino carbamates of R-configuration were recovered. Final selective cleavage of the N-allyloxycarbonyl moiety was carried out under mild reaction conditions, which demonstrates the high versatility and potential of this chemoenzymatic route as a source of intermediates in the synthesis of related optically active nitrogenated derivatives.

Subtype-selective NMDA receptor ligands and the use thereof

The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

Synthesis of asymmetrized 2-benzyl-1,3-diaminopropane by a chemoenzymatic route: A tool for combinatorially developing peptidomimetics

Both enantiomers of monoacetamide 5, together with 'dipeptides' 30a,b and monocarbamates 24, (R)-43 and (S)-43, all derived from 2-benzyl-1,3- diaminopropane 4, were synthesized by a chemoenzymatic route starting from the known monoacetate 12. The behaviour of 4 and of the bis(acylated) derivatives 8-11 with respect to hydrolytic enzymes is also presented, together with an extensive study on the configurational stability of monoacylated derivatives of 4.