83442-72-2

Usage

Uses

Used in Chemical Research:
(4-chlorophenyl)alanine ethyl ester is used as a building block for organic synthesis, contributing to the development of novel chemical compounds and materials.
Used in Pharmaceutical Industry:
(4-chlorophenyl)alanine ethyl ester is used as a precursor in the development of new drugs, potentially leading to advancements in medicinal chemistry and therapeutic applications.
Used in Biochemistry:
(4-chlorophenyl)alanine ethyl ester is used as a study subject for amino acid derivatives, aiding in the understanding of their properties and potential roles in biological systems.
Used in Material Science:
(4-chlorophenyl)alanine ethyl ester is used in the creation of new materials, potentially offering novel properties and applications in various industries.
Used as a Reagent in Chemical Reactions:
(4-chlorophenyl)alanine ethyl ester is used as a reagent, facilitating specific chemical reactions and processes in the laboratory and industrial settings.

Upstream product

• 106-47-8 4-chloro-aniline 
• 535-11-5 Ethyl 2-bromopropionate 
• 6111-99-5 ethyl diazoalaninate 

Downstream Products

• 93151-14-5 N.N-Diethyl-N'-<2-(4-chlor-anilino)-propionyl>-ethylendiamin 
• 96077-27-9 (+/-)-2-(4-Chlor-anilino)-propionsaeure-(2-dimethylamino-ethylester) 
• 71331-43-6 (+/-)-2-(Methyl-(4-chlor-phenyl)-amino)-propionsaeure-ethylester 
• 83442-61-9 2-(4-chlorophenylamino)propanoic acid 
• 6738-78-9 N.N-Diethyl-N'-<2-(4-chlor-N-methyl-anilino)-propionyl>-ethylendiamin 

Relevant academic research and scientific papers

Compound and application thereof

The invention provides a novel compound. The novel compound has certain inhibitory activity for indoleamine 2,3-dioxygenase (IDO) which is oxido-reductase, and accordingly the novel compound can be used for treating diseases related to the indoleamine 2,3-dioxygenase and can be applied to cancer and immunity related diseases.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Iron(III) corroles and porphyrins as superior catalysts for the reactions of diazoacetates with nitrogen- or sulfur-containing nucleophilic substrates: Synthetic uses and mechanistic insights

A thorough mechanistic investigation has been performed on the reactions of primary and secondary amines with diazoacetates, which proceed uniquely quickly and efficiently when catalyzed by iron(III) corroles and porphyrins. Two major differences in relation to other metal-based catalysts are that the iron complexes are not poisoned by excess amine and that metal-carbene intermediates are apparently not involved in the reaction pathway. The results instead point towards nitrogen ylide intermediates formed by nucleophilic attack of the amines on diazoacetate-coordinated iron complexes. Nitrogen ylides are also formed when allyl- and propargylsubstituted tertiary amines react with diazoacetates, a scenario that smoothly leads to 2,3-rearrangement reaction products with catalytic amounts of the iron(III) complexes. Similar findings regarding the superiority of the iron-(III) complexes (in terms of catalyst loading, chemical yields, and reaction conditions) were obtained with thiols (S-H insertion) and sulfides (2,3-rear-rangement reactions), which suggest similar mechanisms operate in these cases.

Kinetics and mechanism of thermal gas-phase elimination of α- and β- (N-arylamino)propanoic acid: Experimental and theoretical analysis

2-(N-Phenylamino)propanoic acid 1a and 3-(N-phenylamino)-propanoic acid 2a together with four of their aryl analogues were pyrolysed in the gas-phase. The reactions were homogeneous and free from catalytic and radical pathways. Analysis of the pyrolysate of 1 showed the elimination products to be carbon monoxide, acetaldehyde and aniline, while the pyrolysate of 2 reveals the formation of acrylic acid in addition to aniline. Theoretical study of the pyrolysis of 2 using an ab initio SCF method lend support to a reaction pathway involving a 4-membered cyclic transition state.

Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity

Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chemical correlation and the optical purity determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of α-aryloxy- alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biological activity and stereoselectivity regarding chloride channel are highly reduced.