83442-72-2

Basic information

• Product Name: (4-chlorophenyl)alanine ethyl ester
• CAS NO: 83442-72-2
• Molecular Weight: 227.691
• Mol File: 83442-72-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-chlorophenyl)alanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)alanine ethyl ester(83442-72-2)
• EPA Substance Registry System: (4-chlorophenyl)alanine ethyl ester(83442-72-2)

Safety Data

• Hazardous Substances Data: 83442-72-2(Hazardous Substances Data)

Usage

General Description

"(4-chlorophenyl)alanine ethyl ester" is a chemical compound that is composed of a 4-chlorophenyl group, an alanine amino acid, and an ethyl ester functional group. It is commonly used in chemical research and as a building block for organic synthesis. (4-chlorophenyl)alanine ethyl ester has potential applications in the pharmaceutical industry for the development of new drugs and in the field of biochemistry for the study of amino acid derivatives. Additionally, it may also have uses in the creation of new materials or as a reagent in chemical reactions. Overall, "(4-chlorophenyl)alanine ethyl ester" is a versatile compound with diverse potential applications in various scientific and industrial fields.

Upstream product

• 6111-99-5 ethyl diazoalaninate 
• 106-47-8 4-chloro-aniline 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 6738-78-9 N.N-Diethyl-N'-<2-(4-chlor-N-methyl-anilino)-propionyl>-ethylendiamin 
• 83442-61-9 2-(4-chlorophenylamino)propanoic acid 
• 71331-43-6 (+/-)-2-(Methyl-(4-chlor-phenyl)-amino)-propionsaeure-ethylester 
• 96077-27-9 (+/-)-2-(4-Chlor-anilino)-propionsaeure-(2-dimethylamino-ethylester) 
• 93151-14-5 N.N-Diethyl-N'-<2-(4-chlor-anilino)-propionyl>-ethylendiamin 

Relevant articles and documents

Compound and application thereof

The invention provides a novel compound. The novel compound has certain inhibitory activity for indoleamine 2,3-dioxygenase (IDO) which is oxido-reductase, and accordingly the novel compound can be used for treating diseases related to the indoleamine 2,3-dioxygenase and can be applied to cancer and immunity related diseases.

Iron(III) corroles and porphyrins as superior catalysts for the reactions of diazoacetates with nitrogen- or sulfur-containing nucleophilic substrates: Synthetic uses and mechanistic insights

A thorough mechanistic investigation has been performed on the reactions of primary and secondary amines with diazoacetates, which proceed uniquely quickly and efficiently when catalyzed by iron(III) corroles and porphyrins. Two major differences in relation to other metal-based catalysts are that the iron complexes are not poisoned by excess amine and that metal-carbene intermediates are apparently not involved in the reaction pathway. The results instead point towards nitrogen ylide intermediates formed by nucleophilic attack of the amines on diazoacetate-coordinated iron complexes. Nitrogen ylides are also formed when allyl- and propargylsubstituted tertiary amines react with diazoacetates, a scenario that smoothly leads to 2,3-rearrangement reaction products with catalytic amounts of the iron(III) complexes. Similar findings regarding the superiority of the iron-(III) complexes (in terms of catalyst loading, chemical yields, and reaction conditions) were obtained with thiols (S-H insertion) and sulfides (2,3-rear-rangement reactions), which suggest similar mechanisms operate in these cases.

Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity

Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chemical correlation and the optical purity determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of α-aryloxy- alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biological activity and stereoselectivity regarding chloride channel are highly reduced.