83450-66-2

Basic information

• Product Name: 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane
• Synonyms: 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane
• CAS NO: 83450-66-2
• Molecular Weight: 391.467
• Mol File: 83450-66-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane(83450-66-2)
• EPA Substance Registry System: 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane(83450-66-2)

Safety Data

• Hazardous Substances Data: 83450-66-2(Hazardous Substances Data)

Upstream product

• 33861-65-3 N-phthaloyl-L-phenylalanine-2-mercaptopyridyl thioester 
• 19693-75-5 2-methoxy-1,3-dioxolane 
• 83450-65-1 3-methyl-5-oxo-7-phenyl-6(S)-phthalimido-1-heptane 

Downstream Products

• 82291-89-2 5(S)-benzamido-2-methyl-4-oxo-6-phenylhexanoic acid 
• 83450-67-3 2-(2-methyl-3-butenyl)-2-<1(S)-benzamido-2-phenylethyl>-1,3-dioxolane 
• 83450-69-5 6(S)-benzamido-3-methyl-5-oxo-7-phenyl-1-heptene 

Relevant articles and documents

Derivatives of the potent angiotensin converting enzyme inhibotor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: Effect of changes at positions 2 and 5 of the hexanoic acid portion

Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had an I50 against angiotensin converting enzyme of 1.0 x 10-9 M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.