83479-97-4Relevant academic research and scientific papers
New and efficient synthesis of 5′-amino-5′-(S)-methyl-2′,5′-dideoxynucleosides
Jung, Pierre M. J.,Beaudegnies, Renaud,De Mesmaeker, Alain,Wendeborn, Sebastian
, p. 293 - 297 (2007/10/03)
A short, efficient synthesis of 5′-amino-5′-(S)-methyl-2′,5′-dideoxynucleosides 1 has been developed through the diastereoselective addition of methylmagnesium bromide or methyllithium to an intermediate tert-butylsulfinimide.
Synthesis of a new hydroxyamino linked thymidine dimer via a radical C-C bond formation
Sanghvi,Cook
, p. 859 - 862 (2007/10/02)
An efficient synthesis of a thymidine nucleoside dimer [T-3'-β-O- N(CH3)-CH2-5'-T] has been accomplished via an intermolecular radical coupling reaction. The novel dimer contains an achiral and neutral backbone linkage which may have potential application in constructing backbone modified antisense oligonucleosides.
Synthesis of an oxyamide linked nucleotide dimer and incorporation into antisense oligonucleotide sequences
Burgess,Gibbs,Metzker,Raghavachari
, p. 915 - 916 (2007/10/02)
Two derivatives of thymidine, a 5'-protected 3'-hydroxylamine and 5'-carboxy-3'-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal t
