83497-59-0Relevant academic research and scientific papers
Organocatalytic asymmetric michael addition of 1-acetylindolin-3-ones to α,β-unsaturated aldehydes: Synthesis of 2-substituted indolin-3-ones
Liu, Yao-Zong,Zhang, Jie,Xu, Peng-Fei,Luo, Yong-Chun
experimental part, p. 7551 - 7555 (2011/11/12)
A highly efficient asymmetric Michael addition of 1-acetylindolin-3-ones to α,β-unsaturated aldehydes is developed to afford 2-substituted indolin-3-one derivatives in high yields (up to 94%) with good stereoselectivities (up to 11:1 dr and 96% ee). The Michael adducts can be transformed into substituted cyclopentyl[b]indoline compounds conveniently without racemization.
