835-42-7Relevant academic research and scientific papers
Direct access to 3-aminoindazoles by Buchwald-Hartwig C-N coupling reaction
Lohou, Elodie,Collot, Valeri,Stiebing, Silvia,Rault, Sylvain
, p. 2651 - 2663 (2011/10/04)
An efficient synthesis of various N-substituted 3-aminoindazoles using Buchwald-Hartwig C-N coupling reaction is described. Several parameters were varied, including the nature of the halogen atom and the protecting group of the starting materials, as well as the effects of the catalyst system, base, solvent, and reaction time. The efficiency of microwave versus conventional heating was also compared to test the outcome of the reaction. Thus, by applying this recent knowledge about metal-catalyzed aminations, an alternative for the direct synthesis of primary 3-aminoindazoles has been provided. Georg Thieme Verlag Stuttgart. New York.
An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles
Burke, Michael J.,Trantow, Brian M.
, p. 4579 - 4581 (2008/09/21)
A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents.
