83502-69-6

Basic information

• Product Name: 1-(4-CHLOROBUTYL)-1H-INDOLE-2,3-DIONE
• Synonyms: 1-(4-CHLOROBUTYL)-1H-INDOLE-2,3-DIONE
• CAS NO: 83502-69-6
• Molecular Formula: C₁₂H₁₂ClNO₂
• Molecular Weight: 237.68
• Mol File: 83502-69-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLOROBUTYL)-1H-INDOLE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROBUTYL)-1H-INDOLE-2,3-DIONE(83502-69-6)
• EPA Substance Registry System: 1-(4-CHLOROBUTYL)-1H-INDOLE-2,3-DIONE(83502-69-6)

Safety Data

• Hazardous Substances Data: 83502-69-6(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 110-56-5 1,4-dichlorobutane 
• 6940-78-9 4-chlorobutyl bromide 
• 10297-05-9 1-chloro 4-iodobutane 

Relevant articles and documents

Synthesis of N-(2-chloroethyl)isatins and their β-ethyleneacetals and β-thiosemicarbazones

The nitrogen atoms of isatin, its 5-bromo derivative, and their β-ethyleneacetals are alkylated by 1,2-dichloroethane in K2CO3-DMF and LiH(NaH)-DMF. 1999 KluwerAcademic/Plenum Publishers.

Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a broad spectrum, are not effective towards all organophosphorus toxins, and have poor pharmacokinetics properties to allow them crossing the blood-brain barrier, hampering cholinesterase reactivation at the central nervous system. In this work, we designed and synthesised novel isatin derivatives, linked to a pyridinium 4-oxime moiety by an alkyl chain with improved calculated properties, and tested their reactivation potency against paraoxon- and NEMP-inhibited acetylcholinesterase in comparison to the standard antidote pralidoxime. Our results showed that these compounds displayed comparable in vitro reactivation also pointed by the in silico studies, suggesting that they are promising compounds to tackle organophosphorus poisoning.

Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents

Derivatives of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole and of (+)enantiomeric, mixtures of (+) and (-)enantiomeric or (±)racemic 2,3,4,4a,5,9b-hexahydro-4a,9b-trans-1H-pyrido[4,3-b]indole, substituted at the 5-position with an aryl group and at the 2-p