83506-37-0Relevant academic research and scientific papers
Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives
George, Riham F.,Saleh, Dalia O.
, p. 663 - 673 (2016/01/09)
Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.
Reaction of 3-Hydrazino-6-phenylpyridazines: Synthesis of s-Triazolopyridazines and 3-Heteroaryl-6-phenylpyridazines
Shams, N. A.,Kaddah, A. M.,Moustafa, A. H.
, p. 317 - 320 (2007/10/02)
3-Hydrazinopyridazines (1a and 1b) react with different acid derivatives to give s-triazolopyridazines (2, 3, 4 and 6) while with α,β-unsaturated carbonyl compounds they give pyrazolylpyridazines (7 and 8).The reaction of 1a with ethyl β-benzoylpro
