83541-10-0

Basic information

• Product Name: (2S,4E)-2-methyl-2-phenyl-4-hexenoic acid
• Synonyms: (2S,4E)-2-methyl-2-phenyl-4-hexenoic acid
• CAS NO: 83541-10-0
• Molecular Weight: 204.269
• Mol File: 83541-10-0.mol

Chemical Properties

• CAS DataBase Reference: (2S,4E)-2-methyl-2-phenyl-4-hexenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4E)-2-methyl-2-phenyl-4-hexenoic acid(83541-10-0)
• EPA Substance Registry System: (2S,4E)-2-methyl-2-phenyl-4-hexenoic acid(83541-10-0)

Safety Data

• Hazardous Substances Data: 83541-10-0(Hazardous Substances Data)

Upstream product

• 492-37-5 hydratropic acid 

Downstream Products

• 83478-46-0 ethyl (2S,4E)-2-methyl-2-phenyl-4-hexenoate 
• 83478-32-4 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester 
• 83478-47-1 (3S,5E)-2,3-dimethyl-3-phenyl-5-hepten-2-ol 
• 83541-11-1 (3R,5E)-2,3-dimethyl-3-phenyl-1,5-heptadiene 
• 83478-44-8 (2S,4E)-2-methyl-2-phenyl-4-hexen-1-ol 

Relevant articles and documents

Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α- C-Allyl Carboxylic Acids

We describe herein the asymmetric synthesis of α-allyl carboxylic acids containing an α-quaternary stereocenter by a chiral hybrid catalyst system comprising palladium and boron complexes. The reaction proceeded through palladium-catalyzed ionization of α,α-disubstituted O-allyl esters for the generation of chiral π-allyl palladium complex as an electrophile, boron-catalyzed enolization of the carboxylate part for the generation of chiral α,α-disubstituted carboxylic acid-derived enolates as a nucleophile, and enantioselective coupling between the thus-generated nucleophile and electrophile. Proper combinations of chiral ligands for the boron and palladium catalysts were crucial. The reaction proceeded chemoselectively at the α-position of the carboxylic acid group.