83546-42-3 Usage
Uses
Used in Antiviral Applications:
2'-Fluoro-5-ethylarabinosyluracil is used as an antiviral agent for its ability to inhibit viral replication by interfering with the synthesis of viral RNA. It has shown good potency and selectivity in in vitro and in vivo studies, making it a promising candidate for the treatment of various viral infections.
Used in Influenza Treatment:
In the field of influenza treatment, 2'-Fluoro-5-ethylarabinosyluracil is used as a therapeutic agent to combat the influenza virus. Its antiviral activity has been demonstrated in studies, offering a potential treatment option for influenza infections.
Used in Hepatitis C Treatment:
2'-Fluoro-5-ethylarabinosyluracil is used as a potential treatment for hepatitis C, where it has shown antiviral activity against the hepatitis C virus. Its ability to inhibit viral replication makes it a promising candidate for further development in this application.
Used in Herpes Simplex Virus Treatment:
In the treatment of herpes simplex virus infections, 2'-Fluoro-5-ethylarabinosyluracil is used as an antiviral agent. Its potential to inhibit the replication of the herpes simplex virus has been recognized, offering a possible therapeutic approach for managing these infections.
Used in Pharmaceutical Industry:
2'-Fluoro-5-ethylarabinosyluracil is used in the pharmaceutical industry as a candidate for the development of new antiviral drugs. Its unique chemical structure and demonstrated antiviral activity make it a valuable asset in the search for effective treatments against various viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 83546-42-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,4 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 83546-42:
(7*8)+(6*3)+(5*5)+(4*4)+(3*6)+(2*4)+(1*2)=143
143 % 10 = 3
So 83546-42-3 is a valid CAS Registry Number.
83546-42-3Relevant academic research and scientific papers
A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D- arabinofuranosyluracil and its 5-substituted nucleosides
Alauddin, Mian M.,Conti, Peter S.,Fissekis, John D.
, p. 285 - 289 (2007/10/03)
Several 2′-deoxy-2′-[18F]fluoro-1-β-D- arabinofuranosyluracil derivatives have been synthesized. Coupling of 1-bromo-2-deoxy-2-[18F]fluoro-3,5-di-O-benzoyl-α-D- arabinofuranose 2 with protected uracil derivatives 3a-e followed by hydrolysis and high-performance liquid chromatography purification produced the radiolabeled nucleosides 4a-e in 15-30% yield (d. c.), > 99% radiochemical purity and 55.5-103.6 GBq/μmol specific activities. Copyright
Antiviral Nucleosides. A Stereospecific, Total Synthesis of 2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl Nucleosides
Howell, Henry G.,Brodfuehrer, Paul R.,Brundidge, Steven P.,Benigni, Daniel A.,Sapino, Chester
, p. 85 - 88 (2007/10/02)
A general, total synthesis of (2'-fluoro-2'-deoxy-β-D-arabinofuranosyl)uracils 1a-d is described.A study of the coupling reaction beetwen 3,5-di-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl bromide (7) and silylated pyrimidines 11a-d has resulted in a high overall yield for the five-step stereospecific synthesis of β-nucleosides.
Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
Watanabe,Su,Reichman,Greenberg,Lopez,Fox
, p. 91 - 94 (2007/10/02)
Synthesis of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils containing a vinyl (4a), 2-halovinyl (4b-d), or ethyl substituent at C-5 was achieved. These nucleosides were found to be about a log order less active than 2'-fluoro-5-iodo-ara-C (FIAC) aga
