83555-74-2

Basic information

• Product Name: 2-(4-METHOXYPHENYL) MORPHOLINE
• Synonyms: 2-(4-METHOXYPHENYL) MORPHOLINE;OTAVA-BB 1055924;4-(Morpholin-2-yl)anisole;4-(Morpholin-2-yl)anisole, 1-Methoxy-4-(morpholin-2-yl)benzene;2-(4-Methoxyphenyl)morpholine HCl
• CAS NO: 83555-74-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Mol File: 83555-74-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 321.7 °C at 760 mmHg
• Flash Point: 127.1 °C
• Appearance: /
• Density: 1.063 g/cm³
• Vapor Pressure: 0.000294mmHg at 25°C
• Refractive Index: 1.511
• PKA: 8.56±0.40(Predicted)
• CAS DataBase Reference: 2-(4-METHOXYPHENYL) MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYPHENYL) MORPHOLINE(83555-74-2)
• EPA Substance Registry System: 2-(4-METHOXYPHENYL) MORPHOLINE(83555-74-2)

Safety Data

• Hazardous Substances Data: 83555-74-2(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl) morpholine is a chemical compound with the molecular formula C11H15NO2. It is a morpholine derivative with a 4-methoxyphenyl group attached to the nitrogen atom. 2-(4-METHOXYPHENYL) MORPHOLINE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and in the production of various industrial chemicals. 2-(4-Methoxyphenyl) morpholine has potential applications in the fields of medicine, agriculture, and chemical manufacturing due to its unique structural and chemical properties.

InChI:InChI=1/C11H15NO2/c1-13-10-4-2-9(3-5-10)11-8-12-6-7-14-11/h2-5,11-12H,6-8H2,1H3

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 1243543-86-3 5-[2-(4-methoxyphenyl)morpholin-4-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one 

Relevant articles and documents

The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents

We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the scaffold were examined rationally to establish a structure-activity relationship with the goal of improving potency and maintaining good physicochemical properties. A number of compounds displayed sub-micromolar activity against Mycobacterium tuberculosis with no cytotoxicity against eukaryotic cells. Non-substituted aromatic rings at C5 and a two-carbon chain connecting a terminal aromatic at C7 were preferred features; the presence of NH at C7 and a lack of substituent at C2 were essential for potency. We identified compounds with acceptable metabolic stability in rodent and human liver microsomes. Our findings suggest that the easily-synthesized triazolopyrimidines are a promising class of potent anti-tubercular agents and warrant further investigation in our search for new drugs to fight tuberculosis.