83556-85-8Relevant articles and documents
Synthesis and Antiarrhythmic Activity of cis-2,6-Dimethyl-α,α-diaryl-1-piperidinebutanols
Hoefle, M. L.,Blouin, L. T.,Fleming, R. W.,Hastings, S.,Hinkley, J. M.,et al.
, p. 12 - 19 (2007/10/02)
A series of α,α-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model.Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best antiarrhythmic
Cis-2,6-dimethyl-α,α-diphenyl-1-piperidinebutanol compounds
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, (2008/06/13)
cis-2,6-Dimethyl-α,α-diphenyl-1-piperidinebutanol; and acid-addition salts. The compounds are pharmacological agents, especially antiarrythmic agents. The compounds can be produced by reacting phenyl lithium or phenylmagnesium halide with cis-γ-(2,6-dimet