835616-39-2

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
6-METHYL-1H-INDAZOL-3-YLAMINE is used as a chemical intermediate for the synthesis of biologically active compounds and pharmaceuticals. Its unique structure and properties make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Synthesis of Biologically Active Compounds:
6-METHYL-1H-INDAZOL-3-YLAMINE is used as a building block in the synthesis of various biologically active compounds. Its presence in the molecular structure can impart specific biological activities, making it a valuable component in the development of new pharmaceuticals.
Used in Drug Discovery:
6-METHYL-1H-INDAZOL-3-YLAMINE is used as a starting material in drug discovery processes. Its unique chemical properties and potential interactions with biological targets make it a valuable tool in the search for new therapeutic agents.
Used in Medicinal Chemistry:
6-METHYL-1H-INDAZOL-3-YLAMINE is used as a key component in the design and synthesis of novel drug candidates. Its versatility and potential for modification make it an attractive option for medicinal chemists working to develop new treatments for various diseases and conditions.
Used in Chemical Synthesis:
6-METHYL-1H-INDAZOL-3-YLAMINE is used as a reagent in various chemical synthesis processes. Its ability to form stable compounds and participate in a range of chemical reactions makes it a useful building block in the creation of new molecules and materials.

Upstream product

• 1219024-58-4 2-[2-(diphenylmethylene)hydrazino]-4-methylbenzonitrile 
• 85070-67-3 2-fluoro-4-methylbenzonitrile 

Relevant academic research and scientific papers

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

Compounds as syk kinase inhibitors

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase.

3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α2-adrenoceptor compared to the imidazoline I1 receptor

A series of 3-[(4,5-dihydroimidazolidin-2-yl)imino]indazoles has been synthesized as positional analogues of marsanidine, a highly selective α2-adrenoceptor ligand. Parent compound 4a and its 4-chloro (4c) and 4-methyl (4d) derivatives display α2-adrenoceptor affinity at nanomolar concentrations (Ki = 39.4, 15.9 and 22.6 nM, respectively) and relatively high α2/I1 selectivity ratios of 82, 115 and 690, respectively. Evidence was obtained that these compounds act as partial agonists at α2A-adrenoceptors. Compound 4d with intrinsic activity comparable with that of marsanidine, but lower than that of clonidine, elicited pronounced cardiovascular effects in anesthetized rats at doses as low as 0.01 mg/kg iv.

A general, one-step synthesis of substituted indazoles using a flow reactor

Flow chemistry is a rapidly emerging technology within the pharmaceutical industry, both within medicinal and development chemistry groups. The advantages of flow chemistry, increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technology in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilises flow chemistry to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogues.

Two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles

A general two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles involving a palladium-catalyzed arylation of benzophenone hydrazone followed by an acidic deprotection/cyclization sequence is described. This procedure offers a general and efficient alternative to the typical S NAr reaction of hydrazine with o-fluorobenzonitriles.