83562-59-8Relevant articles and documents
Sweet (hetero)aromatics: Glycosylated templates for the construction of saccharide mimetics
Wiebe, Christine,Schlemmer, Claudine,Weck, Stefan,Opatz, Till
supporting information; experimental part, p. 9212 - 9214 (2011/10/04)
Mono- and diglycosylated aromatics and heteroaromatics may serve as building blocks for the construction of metabolically stable mimetics of oligosaccharides. Methods for their preparation from monosaccharidic precursors by direct C-glycosylation, dipolar cycloaddition or Larock cyclization are described.
2'-Deoxy-2'-alkoxyaminouridines: Novel 2'-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2'-O-anhydrouridines
Sebesta, David P.,O'Rourke, Sarah S.,Martinez, Rogelio L.,Pieken, Wolfgang A.,McGee, Danny P. C.
, p. 14385 - 14402 (2007/10/03)
Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo- and regiospecific introduction of structural modifications at the 2'-position of uridine nucleosides. A novel class of modified nucleosides, 2'-alkoxylamino-2'-deoxy uridines, are prepared by intramolecular nucleophilic addition of a 3'-tethered alkoxycarbamate nucleophile to the 2'-position with concomitant opening of a 2,2'-anhydrouridine.