83569-58-8Relevant academic research and scientific papers
CF3CO2ZnEt-mediated highly regioselective rearrangement of bromohydrins to aldehydes
Wang, Zhihui,Li, Meiyi,Zhang, Wenqin,Jia, Jiangnan,Wang, Fei,Xue, Song
supporting information; experimental part, p. 5968 - 5971 (2011/11/29)
A highly efficient and selective rearrangement reaction of bromohydrins to aldehydes mediated by CF3CO2ZnEt was described. The secondary and tertiary aldehydes were prepared under mild conditions in good to excellent yields (85-99%). The scope and limitations of this rearrangement process were also investigated.
Remarkable difference of chemoselectivity in the reduction of α-bromo ketones with dibutyltin dihydride system
Shibata, Ikuya,Nakamura, Kenji,Baba, Akio,Matsuda, Haruo
, p. 6381 - 6384 (2007/10/02)
Remarkably different chemoselectivities were noted in the reduction of α-bromo ketones by n-Bu2SnH2 system. Without additive, the reduction of α-bromo group took place. While, the addition of small amounts of p-Dinitrobenzene (DNB) caused the chemoselective reduction of carbonyl group.
Palladium-catalysed oxidation of alcohols with carbon tetrachloride, formation of 4,4,4-trichloro ketones from allylic alcohols and carbon tetrachlorid
nagashima, Hideo,Sato, Koji,Tsuii, Jiro
, p. 5645 - 5651 (2007/10/02)
Pd salts catalyse oxidation of alcohols with CCl4 in the presence of K2CO3. Primary alcohols are oxidised to esters, and secondary alcohols to ketones. CCl4 is converted to CHCl3. The reaction of allylic alcohols bearing a terminal olefinic bond with CCl4 or BrCCl3 in the presence of palladium catalyst at 110° affords 4,4,4-trichloro ketones. At 40°, simple adducts of CCl4 or BrCCl3 having a halohydrin structure are obtained, which are converted to the corresponding trichloro ketones by the catalysis of palladium. Various halohydrins are converted to ketones by Pd catalysis.
