835871-01-7Relevant academic research and scientific papers
COMPOSITION FOR LOWERING BLOOD-SUGAR LEVEL
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Page/Page column 55, (2010/02/10)
The present invention provides compositions, which have an action to lower blood sugar levels in subjects in a hyperglycemic state based on a mechanism that is different from conventional drugs to treat diabetes, and which are used for lowering the blood sugar levels of the subjects. The present invention also provides compositions to prevent or treat diseases caused by hyperglycemia, specifically, diabetes and the complications of diabetes, based on the action above. The invention further provides a method to lower blood sugar levels of subjects in a hyperglycemic state, and a method to prevent or threat diseases caused by hyperglycemia, using a hypoglycemic action based on the novel mechanism of action of the composition. The present invention also provides a method to screen the active ingredient of the above compositions. The present invention provides novel imidazole compounds represented by formula (1), which has an action of lowering the blood sugar level of a subject in a hyperglycemic state, and is useful as an active ingredient of a hypoglycemic composition, or an active ingredient of a composition that can be used for preventing or treating disorders caused by hyperglycemia, specifically diabetes and complications of diabetes.
