835903-15-6Relevant articles and documents
2-(4-Alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists
Zaragoza, Florencio,Stephensen, Henrik,Peschke, Bernd,Rimvall, Karin
, p. 306 - 311 (2005)
With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H3 antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.